Protein Details: β2 (Calcium-activated potassium channel subunit beta-2)

Protein ID

ICDB_Pro_1468

Protein Name

β2 (Calcium-activated potassium channel subunit beta-2)

Gene Name

Kcnmb2

Organism

Mus musculus (Mouse)

Length

235 amino acids

AlphaFoldDB

AF-Q9CZM9-F1-model_v4.pdb

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1; thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity)

Sequence

MFIWTSGRTSSSYRQDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGERLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1126/science.1112014; 10.1101/gr.2596504

RefSeq

NP_082507.1; XP_006535612.1; XP_006535613.1; XP_006535614.1; XP_017175231.1